the highest response with ntz:
-ntz dose 1.5g or 2g (500mg pill) daily with food
- starting ntz when hbvdna is detectable and there are alt flares or hbcab igm>0.2s/co (this means there is an active immune response)
- having hbsag 3log iu/ml or lower, hbeag negative and hbeab positive
- starting ntz 4 weeks before drug active on hbvdna
- combination with peginterferon most potent
- among nucs entecavir o tenofovir combo
best ntz brands: alinia romark, nizonide500 lupin.
purity not verified by alinia group daxon, nitarid cipla, nizonide glenmark, but chemical is very easy so it is not necessary to check purity
test to see if nitazoxanide is working, hbsag quantity by abbott architet in iu/ml
best results so far in monotherapy or combo hbe negative, 2000-2600iu/ml hbsag drop within first 3 months
minimum hbsag drop to see if ntz is working, we don t know but we can use the best rates of interferon and nucs on a minority of 11-17% of patients:
interferon: about 0.5iu/ml hbsag drop by 24 weeks
entecavir or tenofovir: 0.5iu/ml hbsag drop by 48 weeks
ntz is not active on hbvdna or alt directly and alt might get a little higher at start like for interferon or nucs, so monitoring of hbvdna and alt is not good to see ntz response, from our group it looks like hbsag is the first to lower on ntz
+ نوشته شده در دوشنبه یکم تیر ۱۳۹۴ ساعت 21:53 توسط محقق زمینه هپاتیت
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